We are now just a few weeks
past when Christians celebrated the birth of Jesus and reflected on
the wonder of God taking on the form of a human being, especially
starting as a newborn baby born under humble circumstances. But that
human being didn’t start his earthly form at birth, but rather nine
months earlier, as an embryo.
King David expresses it as “unformed substance”
in verse 16 of Psalm 139, an apt description of our early embryonic
morphology. The biological truth is that the existence of every new
human organism did indeed begin at the formation of that first new
organismal cell, the zygote, the combination of the egg and sperm.
The lack of recognizable human structures, the unformed substance of
our earliest existence, does not invalidate the humanity of our
earliest stages of life.
Strange then that early human embryos, our most
vulnerable stage of life and “the least of these” our fellow humans,
have been targeted especially in recent years, as a source of stem
cells that we were told would cure all known maladies. Yet the facts
have been, and continue to be, obscured by proponents of embryonic
stem cell research who are so eager to harvest stem cells from tiny
humans they are blind to the truth that there are plentiful
alternative sources.
Embryonic stem cells have been known to exist
for decades and were studied for many years before being grown
successfully in the lab. One initial point people must realize is
that the isolation of human embryonic stem cells requires the
destruction of a young human embryo, and often many embryos are
destroyed before one successful cell culture is achieved.
And what of the “potential” for cures? After over
30 years, not very many mice have benefited from embryonic stem cell
therapy, and to date there is no proven success with human embryonic
stem cells. Embryonic stem cells are the least likely type of stem
cell to help any patients. Their very nature—a tendency to incessant
growth—means that they are much more likely to form a tumor than to
form healthy tissue, and so embryonic stem cells risk the life and
health of those who are injected with them.
Even some embryonic stem cell advocates are
beginning to admit failure. The California Institute for
Regenerative Medicine, charged with spending $3 billion of state
taxpayer dollars primarily for embryonic stem cell and human cloning
research, has lately been funding mostly grants for non-embryonic
stem cell research, hoping that they will have something to show for
their expenditures which so far have yielded nothing from embryonic
stem cells. Given the ethical taint of embryonic stem cell research,
creating and destroying human life specifically for destruction, the
trend away from embryonic stem cells is encouraging both for ethics
as well as for practical needs of patients.
The new, ethical method of producing iPS cells
(induced pluripotent stem cells) is also encouraging. The iPS cells
are made by adding a few genes to a normal cell such as a skin cell,
causing the normal cell to look and act like an embryonic stem cell,
yet without use of embryos, eggs, or cloning technology. There is
often confusion here. Even though iPS cells use an adult cell (not a
stem cell) as the starting material, they are definitely not
“adult stem cells,” but rather an ethically derived version of
embryonic stem cells.
They can be made from any person, starting with
almost any normal cell, and have already been used in the laboratory
as models to study cell growth, differentiation, and the development
and potential treatment of disease. For example, Israeli scientists
have made iPS cells from heart patients, then turned the iPS cells
into beating heart cells in the lab, to study heart disease.
Adult stem cells remain the gold standard
among stem cells when it comes to helping patients. The first
transplants, using whole bone marrow, were done decades ago, but it
took many years before these transplants were accepted as
therapeutic successes. It wasn’t until the 1990s that doctors began
isolating human adult stem cells, rather than using bone marrow.
Today, adult stem cell transplants remain the only successful use of
stem cells for patients, as documented by hundreds of published,
peer-reviewed scientific articles. Adult stem cells can be isolated
from many different tissues, including bone marrow, blood, muscle,
fat, and umbilical cord blood, and isolating the adult stem cells
from tissues of a patient or a healthy donor does not require
harming or destroying the adult stem cell donor. That gives adult
stem cells a distinct ethical advantage over embryonic stem cells.
Over 60,000 people around the globe are treated each year with adult
stem cells, because adult stem cells have a proven record at saving
lives and improving health.
Here are a few samples of adult stem cell
advances in the last year.
Heart damage. Adult stem cells continue to
pile up the evidence for their success at improving the health of
damaged hearts. Repair of damaged heart muscle in patients has been
documented both for new heart attack damage as well as for patients
with chronic heart failure. Doctors at Cedars-Sinai Hospital in Los
Angeles used adult stem cells from the hearts of the patients
themselves, grown in the lab and then injected back into the
patients’ own hearts. They found that the adult stem cells could
re-grow damaged heart muscle and reduce scars in the heart tissue.
Meanwhile Yale scientists used a young girl’s own bone marrow adult
stem cells to grow heart tissue and blood vessels to repair the
girl’s congenital heart problem. And doctors from the Texas Heart
Institute in Houston presented evidence that adult stem cells from a
patient’s own bone marrow could repair damaged areas of hearts
suffering from severe heart failure, allowing the heart to increase
its pumping capacity to deliver oxygenated blood to the body.
Muscle repair. Scientists at the University
of Pittsburgh School of Medicine have shown that adult stem cells
from the muscle of young mice can improve the health and extend the
life of aged mice. While this doesn’t mean that the cells are truly
the fountain of youth, it highlights the possibility of using adult
stem cells for muscle repair, as well as the ability eventually to
isolate “rejuvenating factors” from adult stem cells in muscle or
other tissues.
New windpipes. Italian Dr. Paolo Macchiarini,
who is a visiting professor at the Karolinska Institute in
Stockholm, Sweden, continues to improve on his procedure to grow new
windpipes for patients. Dr. Macchiarini has grown new trachea for at
least eight patients, using the patient’s own adult stem cells from
bone marrow to grow functional windpipes in patients with cancer or
other tracheal problems. His most recent advance this year was using
a synthetic substrate on which the adult stem cells are seeded,
allowing them to grow and take the shape of a normal windpipe.
Grow your own transfusion. French scientists
showed for the first time that a few adult stem cells from a patient
could be used to grow enough red blood cells in the lab for a
transfusion. The adult stem cells efficiently produced new cells
that survived transfusion back into the patient’s body and
functioned normally.
If you’d like to see a few examples of the
success of adult stem cells, see the videos at
http://www.stemcellresearchfacts.org. Adult stem cells save
lives.