Adult Stem Cells–Best-Kept
Secret, Treating Sickle Cell Anemia
Part Three of Three
By David Prentice
Editor's note. This
first appeared on Dr. Prentice's blog at
http://www.frcblog.com/2010/09/adult-stem-cells%E2%80%93best-kept-secret-treating-sickle-cell-anemia/
September
is Sickle Cell Awareness Month. One aspect of which most aren't
aware is that sickle cell anemia is being successfully treated
with adult stem cells! In her recent Senate testimony, Dr. Jean
Peduzzi Nelson described the case of Joseph Davis, Jr. Joe Jr.
was born with severe sickle cell anemia. His parents were told
that he probably wouldn't live to be a teenager. After a search
for a matching bone marrow donor came up empty, they were able
to use little brother Isaac's umbilical cord blood to
successfully treat Joe Jr., who now leads a normal life. His
brother literally saved his life with adult stem cells.
Sickle cell anemia is a
serious, life-threatening blood disease. It causes pain, chronic
anemia and tiredness, and can lead to severe infections, damage
to organs including the heart, kidneys and lungs, stroke and
death. About 1 in 500 African-Americans has sickle cell anemia.
Adult stem cells are successfully treating sickle cell disease
now. A 2007 report in the journal Blood described extremely
successful results treating sickle cell disease with adult stem
cells, noting that matched donor transplant "is the only
curative treatment for sickle cell disease."
A 2007 review in Bone
Marrow Transplantation noted that:
"Currently, hematopoietic
SCT (HCT) is the only intervention that can restore normal
hematopoiesis to provide a 'cure' in sickle cell disease."
A 2008 published study led
by Dr. Lakshmanan Krishnamurti at the Children's Hospital of
Pittsburgh developed a gentler, easier technique for treating
sickle cell anemia with adult stem cells. Dr. Krishnamurti said:
"This study offers hope
for a cure to thousands of patients with severe sickle cell
disease."
And a 2009 study in the
New England Journal of Medicine showed that the adult stem cell
transplants could work successfully for adults.
Adult stem cells are
saving sickle cell patients now!
Part One
Part Two |