California Boy with Cerebral Palsy
Improves
after Cord Blood Stem Cell Transplant
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By Liz Townsend
More parents are choosing to save
their newborns' umbilical cord blood after studies have shown that it is an
invaluable source of stem cells that could treat a growing number of
diseases. The latest success story comes from Sacramento, California, where
two-year-old Dallas Hextell has triumphed over cerebral palsy with the help
of a stem cell transplant.
Cerebral palsy refers to neurological
disorders that "permanently affect body movement and muscle coordination but
don't worsen over time," according to the web site of the National Institute
of Neurological Disorders and Stroke.
Soon after Dallas was born in 2006,
his parents, Cynthia and Derek Hextell, noticed that he was having severe
physical problems. "He would cry for three hours straight like he was in
pain," Mrs. Hextell said on the Today show. "He couldn't really focus on
things. When he started eating baby food, he had trouble controlling his
tongue."
Doctors diagnosed cerebral palsy, and
the Hextells began to scour the Internet for more information and for hope.
They discovered that Duke University in North Carolina was conducting a
study that uses a child's own umbilical cord blood stem cells to treat
cerebral palsy and other forms of brain damage, according to East Bay
Express.
The Hextells had decided just weeks
before Dallas's birth to spend $2,000 to store his umbilical cord blood. "I
had never even heard of cord blood, but I'm a huge researcher,"
Mrs. Hextell told East Bay Express. She gathered brochures for
different cord blood banks, and decided to use a California-based company
called Cord Blood Registry.
"It's the same as medical insurance or
life insurance--you pay for it but most likely you'll never use it," she
added. "I would rather have spent the money and never used it, than have not
spent the money and regretted that I didn't get it."
They brought Dallas across the country
to Duke in July 2007. He received a transfusion of stem cells that had been
obtained from the stored cord blood. Since the cells came from Dallas,
without harming him at all, there is no threat of immune system rejection.
"He had 191 million [stem cells] put
back into him during the transfusion," Derek Hextell told Today, "and then
there's 15 million left that they keep aside in case in the future they are
ever able to regenerate."
Although the monetary cost of the
procedure was large--about $12,000--the Hextells were soon able to see that
it was worth every penny. "[T]here was such a drastic change within five
days of the procedure taking place," Mr. Hextell said on Today. "It had to
be [the result of the stem cell transfusion], because he wasn't reaching the
milestones that he's reaching now. He was falling further and further
behind. And once we had the procedure done, he started to get closer and
closer to the milestones he was supposed to be reaching."
Five days after the transfusion,
Dallas said his first word, "mama," East Bay Express reported. He continued
to show more signs of awareness and motor skills that had been missing
before the treatment. "His muscle strength has improved greatly and he seems
more alert and aware of what is going on around him," Mrs. Hextell told East
Bay Express. "He also began to laugh at about a week after the infusion. He
never laughed before; he would just kind of screech."
"He had a lot of sensory issues and
would not use his hands to do things, but instead would take your hands and
guide them to do what he wanted," Mrs. Hextell continued. "Since the
procedure he has began to clap his hands and wave, which he did none of
before."
The prognosis for Derek is very good,
since because cerebral palsy is not a progressive disease, once it is
treated there is no reason to expect it will come back. Doctors "said by the
age of seven, that there may be no signs of cerebral palsy at all," Mr.
Hextell said on Today. "So he's on his way, as far as we're concerned."
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