Canadian Study Treats Multiple
Sclerosis with Adult Stem Cells
Editor's note. Please send any thoughts or comments to
daveandrusko@hotmail.com.
By Liz Townsend
Leah Telder, 24, has suffered from
multiple sclerosis (MS) since her teens. The autoimmune disease affects the
central nervous system, and last October Leah could barely walk even with
assistance, had blurry vision and trouble thinking clearly, and was so weak
that she couldn't take care of herself, according to the Vancouver Sun.
But just five months after Leah
received a transfusion of her own bone marrow stem cells as part of a study
in Ottawa sponsored by the MS Scientific Research Foundation, she walked off
a plane in Vancouver, British Columbia, to the great delight of her parents.
"That was amazing," Leah's mother
Jacky told the Sun. "She walked off. ... I mean, there she was, actually
walking."
Leah was the 17th patient to receive
the experimental MS treatment as part the study. The patients undergo
chemotherapy to eradicate their damaged immune systems. Then, stem cells
that had been harvested from their own bone marrow are transplanted back
into their bodies.
The hope is that the stem cells, which
are obtained without harming the human donor, will establish a new, healthy
immune system that can fight the disease, according to the Sun.
The study team is led by Ontario
neurologist Dr. Mark Freedman and bone marrow transplant specialist Dr.
Harold Atkins.
The study will treat 24 patients in
all. Out of the 17 patients that have been treated so far, one patient died
from the massive doses of chemotherapy that are required for treatment while
three others reported that their MS has continued to progress. The other 13,
including Leah Telder, have experienced great improvement, the Sun
reported.
"I haven't felt this good since before
I was diagnosed," Leah told the Sun. She was visiting her family in
British Columbia for a brief time, since the study protocols require that
she stay in Ottawa for observation for a year.
Leah can now walk unassisted, is able
to speak and think clearly, and can take care of her own basic needs once
more. Although some of her vision was lost as a result of nerve damage, she
has regained much of her sight, according to the Sun.
In addition to her physical
improvements, her parents have seen a positive change in her demeanor since
the treatment. "Leah always had a bit of an attitude and it was gone for a
while, and that was sad," Mrs. Telder told the Sun. "Now she is
herself again."
The researchers plan to formally
publish results of the study this summer, the Sun reported.
Leah's remarkable progress has raised
hopes that this adult stem cell treatment will be beneficial to many MS
patients. As one of the study doctors told Leah, according to the Sun,
"I just wanted to tell you that, yes, you do still have MS, but no one would
be able to tell."
Any ideas or suggestions, please send
them to daveandrusko@hotmail.com.
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