Patient's Own Stem Cells May Reverse Type 1
Diabetes
Part Two of TwoIf my audience would
tolerate it, I could write almost every day about a new
breakthrough using stem cell from sources other human embryos.
But these latest results are so exciting I had to briefly share
the results with you.
Diabetes is a nasty disease, the incidence of
which is growing and growing. Writing in the current issue of
the Journal of the American Medical Association, a research team
from the University of Sao Paulo in Brazil and Northwestern
University in Chicago has used injections of patients' own stem
cells which resulted in patients left "treatment-free -- no
insulin, no immune suppression for almost five years," according
to Dr. Richard Burt, one of the co-authors from Northwestern
University.
Beta cells produce insulin which break down
the glucose in the food we eat. In type I diabetes, the
patient's own immune system turns on the beta cells.
The study is a follow up to a 2007 study where
15 type 1 diabetes patients received their own stem cells "and
no longer needed insulin to control their blood sugar levels,"
according to TIME magazine. Not only did the new study find the
same success in eight more patients, it "also confirmed that in
the majority of them, the stem cell transplant led to an
appreciable repopulation of functioning insulin-producing beta
cells in the pancreas."
To simplify a complicated study, researchers
believe that what triggers the attack in type I diabetes lies
somewhere within the immune cells. So, as with some forms of
cancer, "one possible treatment for the disease may be to wipe
out the entire existing immune system and replace it with a
fresh one, derived from stem cells without this destructive
trait," according to TIME's Alice Park. That's what Voltarelli's
team did with remarkable success.
"Twelve were able to stay off insulin therapy
for three years, and eight needed only intermittent help from
insulin treatments during the five-year study period," she
writes." On average, the patients remained free of insulin
injections for 31 months." Park described this as "a milestone
in diabetes treatment."
"I wouldn't use the word cure," Dr. Burt said.
"But it appears we changed the natural history of the disease."
Part One |